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HIV Infection: History, pathogenesis and prevention (1 credit hours)
This course describes the evolution and spread of HIV (Human Immunodeficiency Virus) and examines the biology of HIV, including the sequence of events following infection of a target cell as well as clinical events after infection. Epidemiological considerations include principle risk populations and changes in the incidence of HIV in these groups. In order for health care providers to better understand the effective methods of preventing HIV infection, common modes of transmission and risk factors are detailed.

Planners, content specialists and feedback personnel have declared that there is no conflict of interest in the preparation and content of this module. There is no commercial support for or endorsement of products in this module.

Dan Becker, D.D.S

Dr. Becker received his bachelor of science in zoology from Ohio University in 1968 and his doctor of dental surgery from Ohio State University in 1972. Although Dr. Becker is a dentist, his interest always centered on academia and he began teaching biology at Sinclair Community College (Dayton, OH) as a part-time instructor in the autumn of 1972. He accepted a full-time faculty position in the Dental Hygiene department in 1976, but continued his teaching within the Biology department as well.

Dr. Becker's interest in pharmacology and anesthesia attracted him to Miami Valley Hospital where he became involved with their dental residency instructing dental residents and learning from mentors during rotations within departments of anesthesia and emergency medicine. During this time, he developed and taught courses in pharmacology and pathophysiology for nursing and other allied health programs until his teaching at Sinclair became entirely devoted to these subject areas. Currently he is a full professor at Sinclair Community College and Associate Director of Education at Miami Valley Hospital. He has published in numerous scientific journals and textbooks, and lectures extensively throughout the United States and Canada.

Upon completion of this module, readers will be able to:
  • Describe important events associated with the evolution and spread of HIV infection.
  • Based on familiarity with the biology of HIV, state the sequence of events following HIV infection of a target cell.
  • Describe the clinical events following HIV infection.
  • State common modes of transmission and cite risk factors for health care providers.
  • Regarding epidemiology, identify three principle risk groups associated with HIV infection and recognize changes in incidence for each group.
  • Identify effective means for preventing HIV infection and describe current treatment strategies.

Chinen J, Shearer WT. Molecular virology and immunology of HIV infection. J Allergy Clin Immunol 2002;110:189-98.

Esparza J, Bhamarapravati N. Accelerating the development and future availability of HIV-1 vaccines: why, when, where, and how? Lancet. 2000; Jun 10;355(9220):2061-6.

Fauci AS. The AIDS epidemic: Considerations for the 21st century. N Engl J Med. 1999; 341(14):1046-50.

Fauci AS, Lane HC. Human immunodeficiency virus (HIV) disease: AIDS and related disorders. In: Fauci AS, Braunwald E, Isselbacher KJ, et al Eds. Harrison's Textbook of Internal Medicine. 14th edition. New York: McGraw Hill Book Co.; 1998.

Goldman L, Bennett JC Editors. Cecil Textbook of Medicine. 21st edition. Philadelphia: W.B. Saunders Co., 2001.


Morbidity Mortality Weekly Report. May 1998;47(RR-7)


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